The average bus between Siena and Frankfurt am Main takes 19h 3m and the fastest bus takes 18h 35m. The bus service runs several times per day from Siena to Frankfurt am Main. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Siena and Frankfurt am Main. The earliest departure is at 11:40 AM in the morning, and the last departure from Siena is at 6:10 PM which arrives into Frankfurt am Main at 1:30 PM. All services require a transfer at Florence Villa Constanza Bus Station and take an average of 19h 3m. The schedules shown below are for the next available departures.
Arrives next day

18h 35m • 1 change
Arrives next day

19h 20m • 1 change
Arrives next day

18h 35m • 1 change
Arrives next day

19h 20m • 1 change
Arrives next day

18h 35m • 1 change
Arrives next day

19h 20m • 1 change
Want to know about travelling from Siena to Frankfurt am Main? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Siena to Frankfurt am Main. However, there are services departing from Siena station and arriving at Frankfurt am Main station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 19h 3m.
Siena to Frankfurt am Main bus services, operated by FlixBus, depart from Siena station.
Siena to Frankfurt am Main bus services, operated by FlixBus, arrive at Mühlheim am Main station.
Book your Siena to Frankfurt am Main bus tickets online with FlixBus.
The distance between Siena and Frankfurt am Main is 782.2 km. The road distance is 1,131 km.
You can take a bus from Siena to Frankfurt Konstablerwache via Florence Villa Constanza Bus Station, Mühlheim am Main, Mühlheim, Offenbach, and Offenbach in around 11h 34m.