The average bus between Siena and Lepanto takes 3h 54m and the fastest bus takes 3h 14m. The bus service runs several times per day from Siena to Lepanto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Siena and Lepanto. The earliest departure is at 5:35 AM in the morning, and the last departure from Siena is at 10:25 PM which arrives into Lepanto at 5:47 AM. All services require a transfer, and take on average 3h 54m. The schedules shown below are for the next available departures.

3h 32m • 1 change

3h 17m • 1 change

3h 32m • 1 change

3h 26m • 1 change

3h 50m • 1 change

3h 32m • 1 change

3h 17m • 1 change

3h 32m • 1 change

3h 50m • 1 change

3h 32m • 1 change

3h 17m • 1 change

3h 32m • 1 change

3h 50m • 1 change

3h 32m • 1 change

3h 17m • 1 change

3h 32m • 1 change

3h 45m • 1 change

3h 31m • 1 change

3h 22m • 1 change

3h 42m • 1 change

3h 45m • 1 change

3h 31m • 1 change

3h 22m • 1 change

3h 42m • 1 change
Want to know about travelling from Siena to Lepanto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Siena to Lepanto. However, there are services departing from Siena station and arriving at Lepanto station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 3h 54m.
Siena to Lepanto bus services, operated by FlixBus, depart from Siena station.
Siena to Lepanto bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
The distance between Siena and Lepanto is 181.8 km. The road distance is 237 km.
FlixBus operates a bus from Siena to Roma, Autostazione Tiburtina every 3 hours. Tickets cost €19–35 and the journey takes 2h 50m. AutoLinee Moretti also services this route 3 times a week.