The average bus between Siena and Medicina takes 4h 38m and the fastest bus takes 3h 10m. The bus service runs several times per day from Siena to Medicina. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Siena and Medicina. The earliest departure is at 6:30 AM in the morning, and the last departure from Siena is at 6:40 PM which arrives into Medicina at 8:25 AM. All services require a transfer, and take on average 4h 38m. The schedules shown below are for the next available departures.

3h 40m • 1 change

3h 35m • 1 change

3h 50m • 1 change

4h • 1 change

3h 50m • 1 change

3h 35m • 1 change

3h 50m • 1 change

4h • 1 change

3h 35m • 1 change

3h 51m • 1 change
Arrives next day

12h 8m • 1 change

3h 35m • 1 change

3h 50m • 1 change

4h • 1 change

3h 51m • 1 change

3h 40m • 1 change

3h 35m • 1 change

3h 50m • 1 change

4h • 1 change

3h 35m • 1 change

3h 45m • 1 change

4h • 1 change

3h 50m • 1 change

3h 35m • 1 change

3h 45m • 1 change

4h • 1 change

3h 50m • 1 change
Want to know about travelling from Siena to Medicina? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Siena to Medicina. However, there are services departing from Siena station and arriving at Medicina station via Bologna Centrale. The journey, including transfers, takes approximately 4h 38m.
Siena to Medicina bus services, operated by FlixBus, depart from Siena station.
Siena to Medicina bus services, operated by FlixBus, arrive at Medicina Fronte Stazione station.
The distance between Siena and Medicina is 131.1 km. The road distance is 193 km.
You can take a bus from Siena to Medicina Fronte Stazione via Bologna Autostazione in around 3h 41m.