The average bus between Siena and Sansepolcro takes 3h 53m and the fastest bus takes 2h 15m. The bus service runs several times per day from Siena to Sansepolcro. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Siena and Sansepolcro. The earliest departure is at 6:24 AM in the morning, and the last departure from Siena is at 7:51 PM which arrives into Sansepolcro at 7:21 AM. All services require a transfer, and take on average 3h 53m. The schedules shown below are for the next available departures.

3h 25m • 1 change
4h 22m • 1 change
2h 32m • 1 change
3h 8m • 1 change
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3h 13m • 1 change
2h 23m • 1 change
3h 8m • 1 change
2h 15m • 1 change
4h 22m • 1 change
2h 32m • 1 change
3h 8m • 1 change
3h 25m • 1 change
4h 22m • 1 change
2h 32m • 1 change
3h 8m • 1 change
3h 25m • 1 change
4h 22m • 1 change
2h 32m • 1 change
3h 8m • 1 changeWant to know about travelling from Siena to Sansepolcro? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Siena to Sansepolcro. However, there are services departing from Siena station and arriving at Sansepolcro station via Arezzo Terminal. The journey, including transfers, takes approximately 3h 53m.
Siena to Sansepolcro bus services, operated by Autolinee Toscane, depart from Porta Ovile station.
Siena to Sansepolcro bus services, operated by Autolinee Toscane, arrive at Sansepolcro Via Marconi station.
The distance between Siena and Sansepolcro is 71.1 km. The road distance is 120 km.
You can take a bus from Porta Ovile to Sansepolcro Via Marconi via Arezzo Terminal in around 3h 15m.