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Sistine Chapel to Florence buses

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Trip Overview

The average bus between Sistine Chapel and Florence takes 4h 35m and the fastest bus takes 4h. There is a bus service every few hours from Sistine Chapel to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 35m
Duration
287 km
Distance
€30
Average price
Hourly
Frequency

Line 62 bus, bus

best
  1. Take the bus from Cavalleggeri/Fornaci to Roma, Autostazione Tiburtinabus bus 62
  2. Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus bus 510 / ...
4h 45m
€16–44

Sistine Chapel to Florence bus times

Buses run hourly between Sistine Chapel and Florence. The earliest departure is at 5:48 AM in the morning, and the last departure from Sistine Chapel is at 10:05 PM which arrives into Florence at 2:10 AM. All services require a transfer at Cavalleggeri/Fornaci and take an average of 4h 35m. The schedules shown below are for the next available departures.

Departing Tuesday, October 13, 2026

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    Arrives next day

    ATAC S.p.A. Azienda per la mobilitàFlixBus5h 7m • 1 change

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    Arrives next day

    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 51m • 1 change

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    Arrives next day

    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 51m • 1 change

Departing Wednesday, October 14, 2026

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 11m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 19m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 35m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 20m • 1 change
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Departing Thursday, October 15, 2026

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 26m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 11m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 19m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 35m • 1 change
  • Show more

Departing Friday, October 16, 2026

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 26m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 11m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 19m • 1 change

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    ATAC S.p.A. Azienda per la mobilitàFlixBus4h 35m • 1 change
  • Show more

Frequently asked questions

Want to know about travelling from Sistine Chapel to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Sistine Chapel to Florence.ExpandLaunch map view
  • Distance: 287.2 km
  • Duration: 4h 35m

What companies run services between Sistine Chapel, Vatican City and Florence, Italy?

You can take a vehicle from Sistine Chapel to Florence Villa Constanza Bus Station via Cavalleggeri/Fornaci and Roma, Autostazione Tiburtina in around 4h 45m.

Operators