Sistine Chapel to Florence Buses

Sistine Chapel to Florence buses

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Trip Overview

The average bus between Sistine Chapel and Florence takes 4h 31m and the fastest bus takes 4h. There is a bus service every few hours from Sistine Chapel to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 31m
Duration: 287 km
Distance: €32
Average price: Hourly
Frequency

Line 62 bus, bus

best

Take the bus from Cavalleggeri/Fornaci to Roma, Autostazione Tiburtinabus 62
Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus 510 / ...

4h 42m

€16–48

Sistine Chapel to Florence bus times

Buses run hourly between Sistine Chapel and Florence. The earliest departure is at 5:43 AM in the morning, and the last departure from Sistine Chapel is at 10:08 PM which arrives into Florence at 2:10 AM. All services require a transfer at Cavalleggeri/Fornaci and take an average of 4h 31m. The schedules shown below are for the next available departures.

Departing Sunday, October 25, 2026

5:43 AM → 10:15 AM
4h 31m • 1 change
6:40 AM → 10:45 AM
4h 4m • 1 change
7:01 AM → 11:10 AM
4h 8m • 1 change
7:59 AM → 12:15 PM
4h 15m • 1 change
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Departing Monday, October 26, 2026

5:48 AM → 10:15 AM
4h 26m • 1 change
6:58 AM → 11:10 AM
4h 11m • 1 change
7:25 AM → 11:45 AM
4h 19m • 1 change
7:39 AM → 12:15 PM
4h 35m • 1 change
Show more

Departing Tuesday, October 27, 2026

5:48 AM → 10:15 AM
4h 26m • 1 change
6:58 AM → 11:10 AM
4h 11m • 1 change
7:25 AM → 11:45 AM
4h 19m • 1 change
7:39 AM → 12:15 PM
4h 35m • 1 change
Show more

Departing Wednesday, October 28, 2026

6:58 AM → 11:10 AM
4h 11m • 1 change
7:25 AM → 11:45 AM
4h 19m • 1 change
7:39 AM → 12:15 PM
4h 35m • 1 change
8:24 AM → 12:45 PM
4h 20m • 1 change
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Departing Thursday, October 29, 2026

5:48 AM → 10:15 AM
4h 26m • 1 change
6:58 AM → 11:10 AM
4h 11m • 1 change
7:25 AM → 11:45 AM
4h 19m • 1 change
7:39 AM → 12:15 PM
4h 35m • 1 change
Show more

Departing Friday, October 30, 2026

5:48 AM → 10:15 AM
4h 26m • 1 change
6:58 AM → 11:10 AM
4h 11m • 1 change
7:25 AM → 11:45 AM
4h 19m • 1 change
7:39 AM → 12:15 PM
4h 35m • 1 change
Show more

Departing Saturday, October 31, 2026

5:48 AM → 10:15 AM
4h 26m • 1 change
7:09 AM → 11:10 AM
4h • 1 change
7:28 AM → 11:45 AM
4h 16m • 1 change
7:47 AM → 12:15 PM
4h 27m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Sistine Chapel to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.