The average bus between Skopje Region and Niš takes 4h 44m and the fastest bus takes 4h 4m. The bus service runs several times per day from Skopje Region to Niš. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Skopje Region and Niš. The earliest departure is at 7:15 AM in the morning, and the last departure from Skopje Region is at 11:20 PM which arrives into Niš at 11:42 AM. All services require a transfer, and take on average 4h 44m. The schedules shown below are for the next available departures.

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4h 32m • 1 changeWant to know about travelling from Skopje Region to Niš? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Skopje Region to Niš. However, there are services departing from Skopje, Transporten Centar station and arriving at Niš, Autobuska Stanica station via Niš, Autobuska Stanica station. The journey, including transfers, takes approximately 4h 44m.
Skopje Region to Niš bus services, operated by Niš-ekspres, depart from Skopje, Transporten Centar station.
Skopje Region to Niš bus services, operated by Niš-ekspres, arrive at Niš, Autobuska Stanica station.
The distance between Skopje Region and Niš is 151.7 km. The road distance is 189 km.
Niš-ekspres operates a bus from Skopje, Transporten Centar to Niš, Autobuska Stanica 4 times a day. Tickets cost RSD 2,200–3,200 and the journey takes 3h 57m. AD Galeb Ohrid also services this route once daily.