The average bus between Slough and Plymouth takes 5h 47m and the fastest bus takes 5h 16m. The bus service runs several times per day from Slough to Plymouth. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Slough and Plymouth. The earliest departure is at 8:34 AM in the morning, and the last departure from Slough is at 10:32 PM which arrives into Plymouth at 4:05 AM. All services require a transfer, and take on average 5h 47m. The schedules shown below are for the next available departures.

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6h 32m • 1 changeWant to know about travelling from Slough to Plymouth? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Slough to Plymouth. However, there are services departing from Slough station and arriving at Plymouth station via Plymouth Coach Station station. The journey, including transfers, takes approximately 5h 47m.
Slough to Plymouth bus services, operated by First Berkshire & The Thames Valley, depart from Heathrow Central Bus Station.
Slough to Plymouth bus services, operated by First Berkshire & The Thames Valley, arrive at Plymouth Coach Station.
Book your Slough to Plymouth bus tickets online with First Berkshire & The Thames Valley and National Express.
The distance between Slough and Plymouth is 278.9 km. The road distance is 355 km.
National Express operates a bus from Heathrow Central Bus Station to Plymouth Coach Station hourly. Tickets cost £40–100 and the journey takes 5h 35m.