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South Boston to St. Louis buses

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Trip Overview

The average bus between South Boston and St. Louis takes 31h 23m and the fastest bus takes 27h 45m. The bus service runs several times per day from South Boston to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

31h 23m
Duration
1,262 mi
Distance
$280
Average price
3 times a day
Frequency

South Boston to St. Louis bus times

Buses run 3 times a day between South Boston and St. Louis. The earliest departure is at 10:00 AM in the morning, and the last departure from South Boston is at 11:00 PM which arrives into St. Louis at 8:15 AM. All services require a transfer at New York and take an average of 31h 23m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Peter Pan Bus LinesGreyhound USA34h 15m • 1 change

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA30h 10m • 1 change
  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA29h 50m • 1 change
  •  → 

    Arrives +2 days

    Peter Pan Bus LinesGreyhound USA34h 15m • 1 change

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA30h 10m • 1 change
  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA29h 50m • 1 change
  •  → 

    Arrives +2 days

    Peter Pan Bus LinesGreyhound USA34h 15m • 1 change

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA30h 10m • 1 change
  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA29h 50m • 1 change
  •  → 

    Arrives +2 days

    Peter Pan Bus LinesGreyhound USA36h 15m • 1 change

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA30h 10m • 1 change
  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA29h 50m • 1 change
  •  → 

    Arrives +2 days

    Peter Pan Bus LinesGreyhound USA36h 15m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA30h 10m • 1 change
  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA29h 50m • 1 change
  •  → 

    Arrives +2 days

    Peter Pan Bus LinesGreyhound USA36h 15m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Peter Pan Bus LinesGreyhound USA30h 10m • 1 change

Frequently asked questions

Want to know about travelling from South Boston to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from South Boston to St. Louis.ExpandLaunch map view
  • Distance: 1,261.7 mi
  • Duration: 31h 23m

What companies run services between South Boston, MA, USA and St. Louis, MO, USA?

You can take a bus from Boston to St Louis Bus Station via New York and Port Authority Bus Terminal in around 28h.

Operators