The average bus between South San Francisco and Milpitas takes 4h 18m and the fastest bus takes 3h 13m. The bus runs at least 2 times per hour from South San Francisco to Milpitas. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 30 minutes between South San Francisco and Milpitas. The earliest departure is at 12:08 AM at night, and the last departure from South San Francisco is at 8:40 PM which arrives into Milpitas at 12:37 AM. All services require a transfer at Palo Alto Transit Center and take an average of 4h 18m. The schedules shown below are for the next available departures.


3h 40m • 2 changes


3h 39m • 2 changes


3h 38m • 2 changes


3h 38m • 2 changes
Want to know about travelling from South San Francisco to Milpitas? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from South San Francisco to Milpitas. However, there are services departing from South San Francisco station and arriving at Milpitas station via Palo Alto Transit Ctr-Bay 1. The journey, including transfers, takes approximately 4h 18m.
South San Francisco to Milpitas bus services, operated by SamTrans, depart from San Bruno BART-Bay 8 Outer Busway station.
South San Francisco to Milpitas bus services, operated by SamTrans, arrive at Santa Clara & 1st station.
The distance between South San Francisco and Milpitas is 50.9 km. The road distance is 79 km.
You can take a bus from San Bruno BART-Bay 8 Outer Busway to Main & Serra via Palo Alto Transit Center, Santa Clara & 1st, and 1st & Santa Clara in around 4h 13m.