The average bus between South San Francisco and Napa takes 4h 47m and the fastest bus takes 2h 30m. The bus service runs several times per day from South San Francisco to Napa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between South San Francisco and Napa. The earliest departure is at 5:29 AM in the morning, and the last departure from South San Francisco is at 9:35 PM which arrives into Napa at 6:39 AM. All services require a transfer at Mission St & 1st St and take an average of 4h 47m. The schedules shown below are for the next available departures.


3h 11m • 2 changes


2h 30m • 2 changes
Arrives next day


9h 3m • 2 changes


3h 11m • 2 changes


2h 30m • 2 changes
Arrives next day


11h 21m • 2 changes
Want to know about travelling from South San Francisco to Napa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from South San Francisco to Napa. However, there are services departing from South San Francisco station and arriving at Napa station via Mission St & 1st St. The journey, including transfers, takes approximately 4h 47m.
South San Francisco to Napa bus services, operated by SamTrans, depart from Airport Blvd & Baden Ave station.
South San Francisco to Napa bus services, operated by SamTrans, arrive at Soscol Gateway Transit Ctr station.
The distance between South San Francisco and Napa is 72.2 km. The road distance is 98 km.
You can take a bus from Airport Blvd & Baden Ave to Soscol Gateway Transit Ctr via Mission St & 1st St, San Francisco Ferry Building, Vallejo Transit Center, and Vallejo Ferry Terminal in around 4h 42m.