The average bus between South Station and Middletown takes 3h 16m and the fastest bus takes 2h 40m. The bus service runs several times per day from South Station to Middletown. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between South Station and Middletown. The earliest departure is at 2:15 AM at night, and the last departure from South Station is at 3:05 PM which arrives into Middletown at 6:00 PM. All services require a transfer at Hartford Union Station and take an average of 3h 16m. The schedules shown below are for the next available departures.

4h 25m • 1 change

3h • 1 change

2h 40m • 1 change

3h 2m • 1 change

4h 25m • 1 change

3h • 1 change

2h 40m • 1 change

3h 2m • 1 change

4h 25m • 1 change

3h • 1 change

2h 40m • 1 change

3h 2m • 1 change

4h 25m • 1 change

3h • 1 change

2h 40m • 1 change

3h 2m • 1 change
Want to know about travelling from South Station to Middletown? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from South Station to Middletown. However, there are services departing from South Station station and arriving at Middletown station via Hartford Union Station station. The journey, including transfers, takes approximately 3h 16m.
South Station to Middletown bus services, operated by Greyhound USA, depart from Boston station.
South Station to Middletown bus services, operated by Greyhound USA, arrive at Main St @ opp Ferry St station.
The distance between South Station and Middletown is 158.5 km. The road distance is 187 km.
You can take a bus from Boston to Main St @ opp Ferry St via Hartford Union Station and Main St @ Gold St in around 3h 46m.