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South Yarmouth to Chicago buses

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Trip Overview

The bus between South Yarmouth and Chicago takes 38h 17m. The bus runs, on average, 4 times per week from South Yarmouth to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

38h 17m
Duration
1,098 mi
Distance
$245
Average price
4 times a week
Frequency

South Yarmouth to Chicago bus times

Buses run 4 times a week between South Yarmouth and Chicago. The service departs South Yarmouth at 8:43 PM in the evening, which arrives into Chicago at 10:00:00. All services require a transfer at Hyannis Transportation Center and take an average of 38h 17m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Cape Cod Regional Transit AuthorityPlymouth & BrocktonGreyhound USAGreyhound USA38h 17m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Cape Cod Regional Transit AuthorityPlymouth & BrocktonGreyhound USAGreyhound USA38h 17m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Cape Cod Regional Transit AuthorityPlymouth & BrocktonGreyhound USAGreyhound USA38h 17m • 3 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Cape Cod Regional Transit AuthorityPlymouth & BrocktonGreyhound USAGreyhound USA38h 17m • 3 changes

Frequently asked questions

Want to know about travelling from South Yarmouth to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from South Yarmouth to Chicago.ExpandLaunch map view
  • Distance: 1,098.3 mi
  • Duration: 38h 17m

What companies run services between South Yarmouth, MA, USA and Chicago, IL, USA?

You can take a bus from Main Street, South Yarmouth to Chicago Bus Station via Hyannis Transportation Center, Boston, South Station, Boston, and Cleveland Bus Station in around 26h 7m.

Operators