The average bus between Southampton and Headington takes 3h 2m and the fastest bus takes 2h 40m. There is a bus service every few hours from Southampton to Headington. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Southampton and Headington. The earliest departure is at 2:05 AM at night, and the last departure from Southampton is at 8:30 PM which arrives into Headington at 11:40 PM. All services require a transfer, and take on average 3h 2m. The schedules shown below are for the next available departures.

2h 45m • 1 change

3h 25m • 1 change

3h 15m • 1 change

2h 50m • 1 change

3h • 1 change

2h 45m • 1 change

3h 25m • 1 change

3h 15m • 1 change

3h • 1 change

2h 45m • 1 change

3h 25m • 1 change

3h 15m • 1 change

3h • 1 change

2h 45m • 1 change

3h 5m • 1 change

3h 12m • 1 change
Want to know about travelling from Southampton to Headington? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Southampton to Headington. However, there are services departing from Southampton station and arriving at Headington station via Heathrow Terminal 5. The journey, including transfers, takes approximately 3h 2m.
Southampton to Headington bus services, operated by National Express, depart from Coach Station.
Southampton to Headington bus services, operated by National Express, arrive at Headington Shops station.
The distance between Southampton and Headington is 96.2 km. The road distance is 172 km.
You can take a bus from Coach Station to Headington Shops via Heathrow Terminal 5 in around 2h 42m.