The average bus between Southampton and Milton Keynes takes 5h 19m and the fastest bus takes 4h. The bus service runs several times per day from Southampton to Milton Keynes. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Southampton and Milton Keynes. The earliest departure is at 4:15 AM at night, and the last departure from Southampton is at 8:30 PM which arrives into Milton Keynes at 4:45 AM. All services require a transfer at Heathrow Central Bus Station and take an average of 5h 19m. The schedules shown below are for the next available departures.


5h 14m • 2 changes


5h 8m • 2 changes


5h 29m • 2 changes


5h 52m • 2 changes


4h • 2 changes


4h 44m • 2 changes


5h 4m • 2 changes


5h 14m • 2 changes


4h 30m • 2 changes


4h 43m • 2 changes


5h 10m • 2 changes


5h 13m • 2 changes


4h 44m • 2 changes


5h 4m • 2 changes


5h 25m • 2 changes


5h 14m • 2 changes


5h 34m • 2 changes


5h 14m • 2 changes


4h 29m • 2 changes


4h 10m • 2 changes
Want to know about travelling from Southampton to Milton Keynes? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Southampton to Milton Keynes. However, there are services departing from Southampton station and arriving at Milton Keynes station via Heathrow Central Bus Station station. The journey, including transfers, takes approximately 5h 19m.
Southampton to Milton Keynes bus services, operated by National Express, depart from Coach Station.
Southampton to Milton Keynes bus services, operated by National Express, arrive at Milton Keynes Coachway station.
Book your Southampton to Milton Keynes bus tickets online with National Express, Arriva UK and 2 other operators.
The distance between Southampton and Milton Keynes is 134.2 km. The road distance is 205 km.
You can take a bus from Coach Station to The Point via Heathrow Central Bus Station and Milton Keynes Coachway in around 4h 29m.