The average bus between Southampton and Slough takes 2h 15m and the fastest bus takes 1h 58m. There is a bus service every few hours from Southampton to Slough. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Southampton and Slough. The earliest departure is at 2:20 AM at night, and the last departure from Southampton is at 9:25 PM which arrives into Slough at 11:23 PM. All services require a transfer, and take on average 2h 15m. The schedules shown below are for the next available departures.

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2h 21m • 1 changeWant to know about travelling from Southampton to Slough? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Southampton to Slough. However, there are services departing from Coach Station and arriving at Wellington Street Stop H station via Heathrow Terminal 5 station. The journey, including transfers, takes approximately 2h 15m.
Southampton to Slough bus services, operated by National Express, depart from Coach Station.
Southampton to Slough bus services, operated by Thames Valley Buses, arrive at Wellington Street Stop H station.
Book your Southampton to Slough bus tickets online with Omio.
The distance between Southampton and Slough is 87.8 km. The road distance is 101 km.
You can take a bus from Coach Station to Wellington Street Stop H via Heathrow Terminal 5 in around 2h 5m.