The average bus between Southampton and Slough Station takes 2h 17m and the fastest bus takes 1h 57m. There is a bus service every few hours from Southampton to Slough Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Southampton and Slough Station. The earliest departure is at 2:05 AM at night, and the last departure from Southampton is at 8:30 PM which arrives into Slough Station at 10:40 PM. All services require a transfer at Heathrow Terminal 5 and take an average of 2h 17m. The schedules shown below are for the next available departures.

2h 16m • 1 change

2h 5m • 1 change

2h 20m • 1 change

2h 31m • 1 change

2h 16m • 1 change

2h 5m • 1 change

2h 16m • 1 change

2h 48m • 1 change

2h 16m • 1 change

1h 57m • 1 change

2h 6m • 1 change

2h 27m • 1 change

2h 16m • 1 change

1h 57m • 1 change

2h 5m • 1 change

2h 27m • 1 change
Want to know about travelling from Southampton to Slough Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Southampton to Slough Station. However, there are services departing from Southampton station and arriving at Slough Station station via Heathrow Terminal 5. The journey, including transfers, takes approximately 2h 17m.
Southampton to Slough Station bus services, operated by National Express, depart from Coach Station.
Southampton to Slough Station bus services, operated by National Express, arrive at Wellington Street Stop H station.
Book your Southampton to Slough Station bus tickets online with National Express, Thames Valley Buses and First Berkshire & The Thames Valley.
The distance between Southampton and Slough Station is 88.1 km. The road distance is 115 km.
You can take a bus from Coach Station to Slough Station via Heathrow Terminal 5 and Wellington Street Stop H in around 2h 2m.