The average bus between Southampton and Stoke Mandeville takes 5h 36m and the fastest bus takes 3h 56m. The bus service runs several times per day from Southampton to Stoke Mandeville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Southampton and Stoke Mandeville. The earliest departure is at 4:05 AM at night, and the last departure from Southampton is at 7:35 PM which arrives into Stoke Mandeville at 7:06 AM. All services require a transfer at Heathrow Terminal 5 and take an average of 5h 36m. The schedules shown below are for the next available departures.



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4h 47m • 3 changes


5h 7m • 3 changesWant to know about travelling from Southampton to Stoke Mandeville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Southampton to Stoke Mandeville. However, there are services departing from Southampton station and arriving at Stoke Mandeville station via Heathrow Terminal 5. The journey, including transfers, takes approximately 5h 36m.
Southampton to Stoke Mandeville bus services, operated by National Express, depart from Coach Station.
Southampton to Stoke Mandeville bus services, operated by National Express, arrive at St Mary's Church station.
The distance between Southampton and Stoke Mandeville is 106.9 km. The road distance is 161 km.
You can take a bus from Coach Station to St Mary's Church via Heathrow Terminal 5, Wellington Street Stop F, and High Wycombe BusStn in around 4h 12m.