The average bus between Southampton and Twickenham takes 2h 38m and the fastest bus takes 2h 10m. There is a bus service every few hours from Southampton to Twickenham. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Southampton and Twickenham. The earliest departure is at 2:05 AM at night, and the last departure from Southampton is at 8:30 PM which arrives into Twickenham at 10:57 PM. All services require a transfer, and take on average 2h 38m. The schedules shown below are for the next available departures.

2h 45m • 1 change

2h 17m • 1 change

2h 51m • 1 change

2h 54m • 1 change

2h 45m • 1 change

2h 17m • 1 change

2h 51m • 1 change

2h 54m • 1 change

2h 45m • 1 change

2h 17m • 1 change

2h 51m • 1 change

2h 54m • 1 change

2h 45m • 1 change

2h 17m • 1 change

2h 42m • 1 change

2h 56m • 1 change
Want to know about travelling from Southampton to Twickenham? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Southampton to Twickenham. However, there are services departing from Southampton station and arriving at Twickenham station via Heathrow Terminal 5. The journey, including transfers, takes approximately 2h 38m.
Southampton to Twickenham bus services, operated by National Express, depart from Coach Station.
Southampton to Twickenham bus services, operated by National Express, arrive at Heath Road / Grove Avenue station.
The distance between Southampton and Twickenham is 95.6 km. The road distance is 119 km.
You can take a bus from Coach Station to Heath Road / Grove Avenue via Heathrow Terminal 5 in around 2h 27m.