The average bus between Spagna (Station) and Firenze Santa Maria Novella takes 4h 2m and the fastest bus takes 3h 52m. The bus service runs several times per day from Spagna (Station) to Firenze Santa Maria Novella. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Spagna (Station) and Firenze Santa Maria Novella. The earliest departure is at 12:30 AM at night, and the last departure from Spagna (Station) is at 11:57 PM which arrives into Firenze Santa Maria Novella at 4:55 AM. All services require a transfer at S. Paolo Del Brasile and take an average of 4h 2m. The schedules shown below are for the next available departures.

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Want to know about travelling from Spagna (Station) to Firenze Santa Maria Novella? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Spagna (Station) to Firenze Santa Maria Novella. However, there are services departing from Spagna (Station) station and arriving at Firenze Santa Maria Novella station via Florence. The journey, including transfers, takes approximately 4h 2m.
Spagna (Station) to Firenze Santa Maria Novella bus services, operated by ATAC S.p.A. Azienda per la mobilità, depart from Roma, Autostazione Tiburtina station.
Spagna (Station) to Firenze Santa Maria Novella bus services, operated by ATAC S.p.A. Azienda per la mobilità, arrive at Florence station.
The distance between Spagna (Station) and Firenze Santa Maria Novella is 231.8 km. The road distance is 280 km.
FlixBus operates a bus from Roma, Autostazione Tiburtina to Florence 5 times a day. Tickets cost €22–40 and the journey takes 3h 25m.