Rome2Rio

Springfield to Florence buses

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Trip Overview

The bus between Springfield and Florence takes 41h 55m. The bus runs, on average, 4 times per week from Springfield to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

41h 55m
Duration
1,076 mi
Distance
$217
Average price
4 times a week
Frequency

Springfield to Florence bus times

Buses run 4 times a week between Springfield and Florence. The service departs Springfield at 6:35 PM in the evening, which arrives into Florence at 13:30:00. All services require a transfer at St Louis Bus Station and take an average of 41h 55m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAGreyhound USA41h 55m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAGreyhound USA41h 55m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAGreyhound USA41h 55m • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAGreyhound USA41h 55m • 3 changes

Frequently asked questions

Want to know about travelling from Springfield to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Springfield to Florence.ExpandLaunch map view
  • Distance: 1,076.2 mi
  • Duration: 41h 55m

What companies run services between Springfield, MO, USA and Florence, SC, USA?

You can take a bus from Springfield CU Transit Center to Florence Bus Station via St Louis Bus Station, St. Louis, Carbondale Intermodal Station, and Atlanta Bus Station in around 23h 45m.

Operators