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Springfield to St. Louis (Region) buses

Find Transport to St. Louis (Region)

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Trip Overview

The average bus between Springfield and St. Louis (Region) takes 3h 55m and the fastest bus takes 3h 40m. The bus service runs several times per day from Springfield to St. Louis (Region). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 55m
Duration
227 mi
Distance
$50
Average price
Twice daily
Frequency

Springfield to St. Louis (Region) bus times

Buses run twice daily between Springfield and St. Louis (Region). The earliest departure is at 3:25 AM at night, and the last departure from Springfield is at 6:35 PM which arrives into St. Louis (Region) at 10:45 PM. All services run direct with no transfers required, and take on average 3h 55m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    bus bus 4h 10m • Direct

Departing Friday, November 13, 2026

  •  → 

    bus bus 3h 40m • Direct
  •  → 

    bus bus 4h 10m • Direct

Departing Saturday, November 14, 2026

  •  → 

    bus bus 3h 40m • Direct
  •  → 

    bus bus 4h 10m • Direct

Departing Sunday, November 15, 2026

  •  → 

    bus bus 3h 40m • Direct
  •  → 

    bus bus 4h 10m • Direct

Departing Monday, November 16, 2026

  •  → 

    bus bus 3h 40m • Direct
  •  → 

    bus bus 4h 10m • Direct

Departing Tuesday, November 17, 2026

  •  → 

    bus bus 3h 40m • Direct
  •  → 

    bus bus 4h 10m • Direct

Departing Wednesday, November 18, 2026

  •  → 

    bus bus 3h 40m • Direct

Frequently asked questions

Want to know about travelling from Springfield to St. Louis (Region)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Springfield to St. Louis (Region).ExpandLaunch map view
  • Distance: 227.3 mi
  • Duration: 3h 55m

What companies run services between Springfield, MO, USA and St. Louis (Region), MO, USA?

Greyhound USA operates a bus from Springfield CU Transit Center to St Louis Bus Station twice daily. Tickets cost $40–65 and the journey takes 4h 10m.

Operators