The average bus between St. Catharines and Syracuse takes 6h 2m and the fastest bus takes 5h 31m. The bus service runs several times per day from St. Catharines to Syracuse. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between St. Catharines and Syracuse. The earliest departure is at 8:45 AM in the morning, and the last departure from St. Catharines is at 8:54 PM which arrives into Syracuse at 2:25 AM. All services require a transfer, and take on average 6h 2m. The schedules shown below are for the next available departures.

5h 53m • 1 change

5h 57m • 1 change
Arrives next day

5h 31m • 1 change

5h 53m • 1 change

5h 57m • 1 change
Arrives next day

5h 31m • 1 change

6h 10m • 1 change

6h 42m • 1 change
Arrives next day

5h 34m • 1 change

6h 10m • 1 change

6h 42m • 1 change
Arrives next day

5h 34m • 1 change
Want to know about travelling from St. Catharines to Syracuse? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St. Catharines to Syracuse. However, there are services departing from St. Catharines station and arriving at Syracuse station via Syracuse. The journey, including transfers, takes approximately 6h 2m.
St. Catharines to Syracuse bus services, operated by GO Transit, depart from Niagara Falls station.
St. Catharines to Syracuse bus services, operated by GO Transit, arrive at Syracuse station.
Book your St. Catharines to Syracuse bus tickets online with GO Transit and Trailways.
The distance between St. Catharines and Syracuse is 251.6 km. The road distance is 319 km.
Trailways operates a bus from Niagara Falls to Syracuse 4 times a day. Tickets cost $30–110 and the journey takes 4h 45m.