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St. Louis to Charleston buses

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Trip Overview

The average bus between St. Louis and Charleston takes 35h 39m and the fastest bus takes 33h 43m. The bus runs, on average, 6 times per week from St. Louis to Charleston. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

35h 39m
Duration
1,041 mi
Distance
$226
Average price
6 times a week
Frequency

St. Louis to Charleston bus times

Buses run 6 times a week between St. Louis and Charleston. The service departs St. Louis at 9:00 AM in the morning, which arrives into Charleston at 19:43:42. All services require a transfer at Atlanta Bus Station and take an average of 35h 39m. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

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    Arrives next day

    Greyhound USAGreyhound USACARTACARTA33h 43m • 3 changes

Departing Wednesday, November 4, 2026

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    Arrives next day

    Greyhound USAGreyhound USACARTACARTA33h 43m • 3 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USACARTACARTA33h 43m • 3 changes

Departing Friday, November 6, 2026

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    Arrives next day

    Greyhound USAGreyhound USACARTACARTA33h 54m • 3 changes

Departing Saturday, November 7, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USACARTACARTA45h 9m • 3 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    Greyhound USAGreyhound USACARTACARTA33h 43m • 3 changes

Frequently asked questions

Want to know about travelling from St. Louis to Charleston? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to Charleston.ExpandLaunch map view
  • Distance: 1,041.2 mi
  • Duration: 35h 39m

What companies run services between St. Louis, MO, USA and Charleston, SC, USA?

You can take a bus from St Louis Bus Station to Transit Mall via Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 25h 47m.

Operators