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St. Louis to DeSoto buses

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Trip Overview

The average bus between St. Louis and DeSoto takes 35h 30m and the fastest bus takes 29h 58m. The bus runs, on average, 3 times per week from St. Louis to DeSoto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

35h 30m
Duration
724 mi
Distance
$152
Average price
3 times a week
Frequency

St. Louis to DeSoto bus times

Buses run 3 times a week between St. Louis and DeSoto. The service departs St. Louis at 8:40 AM in the morning, which arrives into DeSoto at 06:15:00. All services require a transfer at Oklahoma City Bus Station and take an average of 35h 30m. The schedules shown below are for the next available departures.

Departing Saturday, October 31, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USADallas Area Rapid Transit (DART)Dallas Area Rapid Transit (DART)46h 35m • 3 changes

Departing Sunday, November 1, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USADallas Area Rapid Transit (DART)Dallas Area Rapid Transit (DART)29h 58m • 3 changes

Departing Monday, November 2, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USADallas Area Rapid Transit (DART)Dallas Area Rapid Transit (DART)29h 58m • 3 changes

Frequently asked questions

Want to know about travelling from St. Louis to DeSoto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to DeSoto.ExpandLaunch map view
  • Distance: 723.7 mi
  • Duration: 35h 30m

What companies run services between St. Louis, MO, USA and DeSoto, TX, USA?

You can take a bus from St Louis Bus Station to Glenn Heights P & R via Oklahoma City Bus Station, Downtown Dallas / Deep Ellum, Gaston @ Good Latimer - S- Ns, Houston @ Young - S - Mb, and Wood @ Record - W - Fs in around 16h 2m.

Operators