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St. Louis to Harrisburg, Pa buses

Find Transport to Harrisburg, Pa

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Trip Overview

The average bus between St. Louis and Harrisburg, Pa takes 19h 48m and the fastest bus takes 19h 20m. The bus service runs several times per day from St. Louis to Harrisburg, Pa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

19h 48m
Duration
805 mi
Distance
$170
Average price
3 times a day
Frequency

St. Louis to Harrisburg, Pa bus times

Buses run 3 times a day between St. Louis and Harrisburg, Pa. The earliest departure is at 2:00 AM at night, and the last departure from St. Louis is at 2:05 PM which arrives into Harrisburg, Pa at 10:25 AM. All services run direct with no transfers required, and take on average 19h 48m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

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    Arrives next day

    bus bus 19h 50m • Direct
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    Arrives next day

    bus bus 19h 20m • Direct

Departing Tuesday, November 10, 2026

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    bus bus 20h 15m • Direct
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    Arrives next day

    bus bus 19h 50m • Direct
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    Arrives next day

    bus bus 19h 20m • Direct

Departing Wednesday, November 11, 2026

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    bus bus 20h 15m • Direct
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    Arrives next day

    bus bus 19h 50m • Direct
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    Arrives next day

    bus bus 19h 20m • Direct

Departing Thursday, November 12, 2026

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    bus bus 20h 15m • Direct
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    Arrives next day

    bus bus 19h 50m • Direct
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    Arrives next day

    bus bus 19h 20m • Direct

Departing Friday, November 13, 2026

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    bus bus 20h 15m • Direct
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    Arrives next day

    bus bus 19h 50m • Direct
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    Arrives next day

    bus bus 19h 20m • Direct

Departing Saturday, November 14, 2026

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    bus bus 20h 15m • Direct
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    Arrives next day

    bus bus 19h 50m • Direct
  •  → 

    Arrives next day

    bus bus 19h 20m • Direct

Departing Sunday, November 15, 2026

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    bus bus 20h 15m • Direct
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    Arrives next day

    bus bus 19h 50m • Direct
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    Arrives next day

    bus bus 19h 20m • Direct

Frequently asked questions

Want to know about travelling from St. Louis to Harrisburg, Pa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to Harrisburg, Pa.ExpandLaunch map view
  • Distance: 804.8 mi
  • Duration: 19h 48m

What companies run services between St. Louis, MO, USA and Harrisburg, Pa, PA, USA?

Greyhound USA operates a bus from St Louis Bus Station to Harrisburg Bus Station 3 times a day. Tickets cost $140–220 and the journey takes 19h 50m.

Operators