Rome2Rio

St. Louis to Louisville, KY buses

Find Transport to Louisville, KY

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Trip Overview

The bus between St. Louis and Louisville, KY takes 23h. The bus runs, on average, 6 times per week from St. Louis to Louisville, KY. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

23h
Duration
284 mi
Distance
$155
Average price
6 times a week
Frequency

St. Louis to Louisville, KY bus times

Buses run 6 times a week between St. Louis and Louisville, KY. The service departs St. Louis at 1:45 PM in the afternoon, which arrives into Louisville, KY at 13:45:00. All services require a transfer, and take on average 23h. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAMiller Transportation23h • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAMiller Transportation23h • 1 change

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAMiller Transportation23h • 1 change

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAMiller Transportation23h • 1 change

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAMiller Transportation23h • 1 change

Departing Monday, November 16, 2026

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    Arrives next day

    Greyhound USAMiller Transportation23h • 1 change

Frequently asked questions

Want to know about travelling from St. Louis to Louisville, KY? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to Louisville, KY.ExpandLaunch map view
  • Distance: 283.9 mi
  • Duration: 23h

What companies run services between St. Louis, MO, USA and Louisville, KY, USA?

You can take a bus from St Louis Bus Station to Louisville, KY via Evansville, IN in around 6h 40m.

Operators