The average bus between St. Louis and Manchester takes 37h 56m and the fastest bus takes 35h 20m. The bus service runs several times per day from St. Louis to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between St. Louis and Manchester. The earliest departure is at 2:00 AM at night, and the last departure from St. Louis is at 2:05 PM which arrives into Manchester at 8:10 AM. All services require a transfer at Port Authority Bus Terminal and take an average of 37h 56m. The schedules shown below are for the next available departures.
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35h 20m • 2 changesArrives +2 days


41h 5m • 2 changesArrives next day


35h 20m • 2 changesArrives +2 days


41h 5m • 2 changesArrives next day


35h 20m • 2 changesArrives +2 days


41h 5m • 2 changesWant to know about travelling from St. Louis to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St. Louis to Manchester. However, there are services departing from St. Louis station and arriving at Manchester station via Port Authority Bus Terminal. The journey, including transfers, takes approximately 37h 56m.
St. Louis to Manchester bus services, operated by Greyhound USA, depart from St Louis Bus Station.
St. Louis to Manchester bus services, operated by Greyhound USA, arrive at Manchester(Veterans Memorial Park) station.
Book your St. Louis to Manchester bus tickets online with Greyhound USA and Peter Pan Bus Lines.
The distance between St. Louis and Manchester is 1,646.4 km. The road distance is 2,119 km.
You can take a bus from St Louis Bus Station to Manchester(Veterans Memorial Park) via Port Authority Bus Terminal, New York, and Boston in around 32h 22m.