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St. Louis to Manchester buses

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Trip Overview

The average bus between St. Louis and Manchester takes 8h 55m and the fastest bus takes 7h 45m. The bus service runs several times per day from St. Louis to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h 55m
Duration
379 mi
Distance
$82
Average price
3 times a day
Frequency

St. Louis to Manchester bus times

Buses run 3 times a day between St. Louis and Manchester. The earliest departure is at 9:00 AM in the morning, and the last departure from St. Louis is at 11:40 PM which arrives into Manchester at 7:25 AM. All services require a transfer, and take on average 8h 55m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA7h 45m • 1 change

Departing Sunday, November 8, 2026

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    Greyhound USAGreyhound USA9h 30m • 1 change
  •  → 

    Greyhound USAGreyhound USA9h 15m • 1 change
  •  → 

    Arrives next day

    Flixbus USAGreyhound USA7h 45m • 1 change

Departing Monday, November 9, 2026

  •  → 

    Greyhound USAGreyhound USA9h 30m • 1 change
  •  → 

    Greyhound USAGreyhound USA9h 15m • 1 change
  •  → 

    Arrives next day

    Flixbus USAGreyhound USA7h 45m • 1 change

Departing Tuesday, November 10, 2026

  •  → 

    Greyhound USAGreyhound USA9h 30m • 1 change
  •  → 

    Greyhound USAGreyhound USA9h 15m • 1 change

Departing Wednesday, November 11, 2026

  •  → 

    Greyhound USAGreyhound USA9h 30m • 1 change
  •  → 

    Greyhound USAGreyhound USA9h 15m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Greyhound USAGreyhound USA9h 30m • 1 change
  •  → 

    Greyhound USAGreyhound USA9h 15m • 1 change
  •  → 

    Arrives next day

    Flixbus USAGreyhound USA7h 45m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Greyhound USAGreyhound USA9h 30m • 1 change

Frequently asked questions

Want to know about travelling from St. Louis to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to Manchester.ExpandLaunch map view
  • Distance: 379.4 mi
  • Duration: 8h 55m

What companies run services between St. Louis, MO, USA and Manchester, TN, USA?

You can take a bus from St Louis Bus Station to Manchester via Nashville Bus Station in around 9h 25m.

Operators