The average bus between St. Louis and Manchester takes 8h 47m and the fastest bus takes 7h 40m. The bus service runs several times per day from St. Louis to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between St. Louis and Manchester. The earliest departure is at 9:00 AM in the morning, and the last departure from St. Louis is at 11:45 PM which arrives into Manchester at 7:25 AM. All services require a transfer, and take on average 8h 47m. The schedules shown below are for the next available departures.

9h 30m • 1 change

9h 15m • 1 change
Arrives next day

7h 40m • 1 change

9h 30m • 1 change

9h 15m • 1 change
Arrives next day

7h 40m • 1 change

9h 30m • 1 change

9h 15m • 1 change
Arrives next day

7h 40m • 1 change

9h 30m • 1 change

9h 15m • 1 change
Arrives next day

7h 40m • 1 change
Want to know about travelling from St. Louis to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St. Louis to Manchester. However, there are services departing from St. Louis station and arriving at Manchester station via Nashville Bus Station station. The journey, including transfers, takes approximately 8h 47m.
St. Louis to Manchester bus services, operated by Greyhound USA, depart from St Louis Bus Station.
St. Louis to Manchester bus services, operated by Greyhound USA, arrive at Manchester station.
Book your St. Louis to Manchester bus tickets online with Greyhound USA and Flixbus USA.
The distance between St. Louis and Manchester is 505.2 km. The road distance is 608 km.
You can take a bus from St Louis Bus Station to Manchester via Nashville Bus Station in around 8h 35m.