The average bus between St. Louis and Massachusetts takes 32h 9m and the fastest bus takes 31h 35m. The bus service runs several times per day from St. Louis to Massachusetts. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between St. Louis and Massachusetts. The earliest departure is at 2:00 AM at night, and the last departure from St. Louis is at 2:05 PM which arrives into Massachusetts at 10:40 PM. All services require a transfer, and take on average 32h 9m. The schedules shown below are for the next available departures.
Arrives next day

33h • 1 change
Arrives next day

34h 5m • 1 change
Arrives next day

32h 35m • 1 change
Arrives next day

33h • 1 change
Arrives next day

34h 5m • 1 change
Arrives next day

32h 35m • 1 change
Arrives next day

33h • 1 change
Arrives next day

34h 5m • 1 change
Arrives next day

32h 35m • 1 change
Want to know about travelling from St. Louis to Massachusetts? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St. Louis to Massachusetts. However, there are services departing from St. Louis station and arriving at Massachusetts station via Port Authority Bus Terminal. The journey, including transfers, takes approximately 32h 9m.
St. Louis to Massachusetts bus services, operated by Greyhound USA, depart from St Louis Bus Station.
St. Louis to Massachusetts bus services, operated by Greyhound USA, arrive at South Station.
Book your St. Louis to Massachusetts bus tickets online with Greyhound USA.
The distance between St. Louis and Massachusetts is 1,588 km. The road distance is 2,035 km.
You can take a bus from St Louis Bus Station to South Station via Port Authority Bus Terminal in around 29h 56m.