Rome2Rio

St. Louis to Port Saint Lucie buses

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Trip Overview

The average bus between St. Louis and Port Saint Lucie takes 28h 53m and the fastest bus takes 25h 23m. The bus runs, on average, 6 times per week from St. Louis to Port Saint Lucie. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

28h 53m
Duration
1,137 mi
Distance
$230
Average price
6 times a week
Frequency

St. Louis to Port Saint Lucie bus times

Buses run 6 times a week between St. Louis and Port Saint Lucie. The service departs St. Louis at 9:00 AM in the morning, which arrives into Port Saint Lucie at 11:47:00. All services require a transfer at Atlanta Bus Station and take an average of 28h 53m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAArea Regional Transit St Lucie25h 47m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAFlixbus USAArea Regional Transit St Lucie25h 47m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAFlixbus USAArea Regional Transit St Lucie25h 23m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives +2 days

    Greyhound USAFlixbus USAArea Regional Transit St Lucie44h 47m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAFlixbus USAArea Regional Transit St Lucie25h 47m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAArea Regional Transit St Lucie25h 47m • 2 changes

Frequently asked questions

Want to know about travelling from St. Louis to Port Saint Lucie? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to Port Saint Lucie.ExpandLaunch map view
  • Distance: 1,136.7 mi
  • Duration: 28h 53m

What companies run services between St. Louis, MO, USA and Port Saint Lucie, FL, USA?

You can take a bus from St Louis Bus Station to SW PSL Blvd & Cameo Blvd - East via Atlanta Bus Station and SW Gatlin Blvd & SW Brescia St in around 24h 54m.

Operators