The average bus between St. Louis and Saint Charles takes 2h and the fastest bus takes 1h 47m. The bus service runs several times per day from St. Louis to Saint Charles. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between St. Louis and Saint Charles. The earliest departure is at 12:21 AM at night, and the last departure from St. Louis is at 9:21 PM which arrives into Saint Charles at 11:09 PM. All services require a transfer, and take on average 2h. The schedules shown below are for the next available departures.

5h 48m • 1 change

1h 48m • 1 change

1h 47m • 1 change

1h 47m • 1 change
Want to know about travelling from St. Louis to Saint Charles? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St. Louis to Saint Charles. However, there are services departing from St. Louis station and arriving at Saint Charles station via North Hanley Transit Center. The journey, including transfers, takes approximately 2h.
St. Louis to Saint Charles bus services, operated by Metro St. Louis, depart from Market @ 14Th Street Wb station.
St. Louis to Saint Charles bus services, operated by Metro St. Louis, arrive at 4375 Rider Trail North Sb station.
The distance between St. Louis and Saint Charles is 30.1 km. The road distance is 35 km.
You can take a bus from Market @ 14Th Street Wb to 4375 Rider Trail North Sb via North Hanley Transit Center in around 1h 36m.