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St. Louis to South Carolina buses

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Trip Overview

The average bus between St. Louis and South Carolina takes 33h 45m and the fastest bus takes 33h 43m. The bus runs, on average, 5 times per week from St. Louis to South Carolina. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

33h 45m
Duration
1,029 mi
Distance
$223
Average price
5 times a week
Frequency

St. Louis to South Carolina bus times

Buses run 5 times a week between St. Louis and South Carolina. The service departs St. Louis at 9:00 AM in the morning, which arrives into South Carolina at 19:43:42. All services require a transfer at Atlanta Bus Station and take an average of 33h 45m. The schedules shown below are for the next available departures.

Departing Monday, November 2, 2026

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    Arrives next day

    Greyhound USAGreyhound USACARTACARTA33h 43m • 3 changes

Departing Tuesday, November 3, 2026

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    Arrives next day

    Greyhound USAGreyhound USACARTACARTA33h 43m • 3 changes

Departing Wednesday, November 4, 2026

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    Arrives next day

    Greyhound USAGreyhound USACARTACARTA33h 43m • 3 changes

Departing Thursday, November 5, 2026

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    Arrives next day

    Greyhound USAGreyhound USACARTACARTA33h 43m • 3 changes

Departing Friday, November 6, 2026

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    Arrives next day

    Greyhound USAGreyhound USACARTACARTA33h 54m • 3 changes

Frequently asked questions

Want to know about travelling from St. Louis to South Carolina? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to South Carolina.ExpandLaunch map view
  • Distance: 1,028.7 mi
  • Duration: 33h 45m

What companies run services between St. Louis, MO, USA and South Carolina, USA?

You can take a bus from St Louis Bus Station to Transit Mall via Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 24h 17m.

Operators