Rome2Rio

St. Louis to Southaven buses

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Trip Overview

The average bus between St. Louis and Southaven takes 6h 37m and the fastest bus takes 5h 13m. There is at least one bus per day from St. Louis to Southaven. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 37m
Duration
296 mi
Distance
$63
Average price
Once daily
Frequency

St. Louis to Southaven bus times

Buses run once daily between St. Louis and Southaven. The earliest departure is at 1:00 AM at night, and the last departure from St. Louis is at 4:00 PM which arrives into Southaven at 9:13 PM. All services require a transfer, and take on average 6h 37m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Greyhound USAMATA Transit6h 13m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Greyhound USAMATA Transit6h 13m • 1 change
  •  → 

    Flixbus USAMATA Transit5h 13m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Greyhound USAMATA Transit6h 13m • 1 change
  •  → 

    Flixbus USAMATA Transit5h 13m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Greyhound USAMATA Transit6h 12m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Flixbus USAMATA Transit13h 13m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Greyhound USAMATA Transit6h 13m • 1 change
  •  → 

    Flixbus USAMATA Transit5h 13m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Greyhound USAMATA Transit6h 13m • 1 change

Frequently asked questions

Want to know about travelling from St. Louis to Southaven? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to Southaven.ExpandLaunch map view
  • Distance: 295.7 mi
  • Duration: 6h 37m

What companies run services between St. Louis, MO, USA and Southaven, MS, USA?

Greyhound USA operates a bus from St Louis Bus Station to Memphis Bus Station once daily. Tickets cost $50–80 and the journey takes 5h 30m. Flixbus USA also services this route 5 times a week.

Operators