Rome2Rio

St. Louis to Winston-Salem buses

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Trip Overview

The bus between St. Louis and Winston-Salem takes 20h 50m. The bus runs, on average, 6 times per week from St. Louis to Winston-Salem. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

20h 50m
Duration
869 mi
Distance
$167
Average price
6 times a week
Frequency

St. Louis to Winston-Salem bus times

Buses run 6 times a week between St. Louis and Winston-Salem. The service departs St. Louis at 9:00 AM in the morning, which arrives into Winston-Salem at 06:50:00. All services require a transfer at Carbondale Intermodal Station and take an average of 20h 50m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    Greyhound USAGreyhound USA20h 50m • 1 change

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAGreyhound USA20h 50m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAGreyhound USA20h 50m • 1 change

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAGreyhound USA20h 50m • 1 change

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAGreyhound USA20h 50m • 1 change

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAGreyhound USA20h 50m • 1 change

Frequently asked questions

Want to know about travelling from St. Louis to Winston-Salem? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to Winston-Salem.ExpandLaunch map view
  • Distance: 868.5 mi
  • Duration: 20h 50m

What companies run services between St. Louis, MO, USA and Winston-Salem, NC, USA?

You can take a bus from St. Louis to Winston Salem(Trans Center) via Carbondale Intermodal Station, Atlanta Bus Station, Garnett Station, Civic Center Station, Atlanta Downtown, and Charlotte Bus Station in around 18h 59m.

Operators