The average bus between St. Louis and Worthington takes 12h 50m and the fastest bus takes 11h 40m. The bus service runs several times per day from St. Louis to Worthington. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between St. Louis and Worthington. The earliest departure is at 2:00 AM at night, and the last departure from St. Louis is at 2:05 PM which arrives into Worthington at 5:55 AM. All services require a transfer at Columbus and take an average of 12h 50m. The schedules shown below are for the next available departures.

13h 5m • 1 change

12h 40m • 1 change
Arrives next day

16h 24m • 1 change

13h 39m • 1 change

12h 49m • 1 change
Arrives next day

15h 50m • 1 change

13h 5m • 1 change

12h 40m • 1 change
Arrives next day

15h 50m • 1 change

13h 5m • 1 change

12h 40m • 1 change
Arrives next day

15h 50m • 1 change

13h 5m • 1 change

12h 40m • 1 change
Arrives next day

15h 50m • 1 change
Want to know about travelling from St. Louis to Worthington? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St. Louis to Worthington. However, there are services departing from St. Louis station and arriving at Worthington station via Columbus. The journey, including transfers, takes approximately 12h 50m.
St. Louis to Worthington bus services, operated by Greyhound USA, depart from St Louis Bus Station.
St. Louis to Worthington bus services, operated by Greyhound USA, arrive at Columbus station.
The distance between St. Louis and Worthington is 638.2 km. The road distance is 700 km.
Greyhound USA operates a bus from St Louis Bus Station to Columbus every 4 hours. Tickets cost $60–130 and the journey takes 9h 40m.