The average bus between St Paul's Cathedral and Manchester takes 5h 37m and the fastest bus takes 5h 5m. There is a bus service every few hours from St Paul's Cathedral to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between St Paul's Cathedral and Manchester. The earliest departure is at 6:24 AM in the morning, and the last departure from St Paul's Cathedral is at 11:30 PM which arrives into Manchester at 6:10 AM. All services require a transfer at Barbican station and take an average of 5h 37m. The schedules shown below are for the next available departures.

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6h 10m • 1 changeWant to know about travelling from St Paul's Cathedral to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St Paul's Cathedral to Manchester. However, there are services departing from St Paul's Cathedral station and arriving at Manchester station via Shudehill Interchange. The journey, including transfers, takes approximately 5h 37m.
St Paul's Cathedral to Manchester bus services, operated by National Express, depart from Finchley Road / O2 Centre station.
St Paul's Cathedral to Manchester bus services, operated by National Express, arrive at Shudehill Interchange station.
Book your St Paul's Cathedral to Manchester bus tickets online with National Express and FlixBus.
The distance between St Paul's Cathedral and Manchester is 262.3 km. The road distance is 326 km.
FlixBus operates a bus from Finchley Road / O2 Centre to Shudehill Interchange hourly. Tickets cost £22–35 and the journey takes 4h 30m.