The average bus between Strasbourg Cathedral and Frankfurt am Main takes 4h 20m and the fastest bus takes 3h 35m. There is a bus service every few hours from Strasbourg Cathedral to Frankfurt am Main. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Strasbourg Cathedral and Frankfurt am Main. The earliest departure is at 12:25 AM at night, and the last departure from Strasbourg Cathedral is at 10:50 PM which arrives into Frankfurt am Main at 3:55 AM. All services require a transfer at Strasbourg and take an average of 4h 20m. The schedules shown below are for the next available departures.

3h 25m • 1 change

2h 40m • 1 change

3h 40m • 1 change

3h 35m • 1 change

3h 25m • 1 change

2h 40m • 1 change

3h 40m • 1 change

3h 35m • 1 change

3h 25m • 1 change

2h 40m • 1 change

3h 40m • 1 change

3h 35m • 1 change
Want to know about travelling from Strasbourg Cathedral to Frankfurt am Main? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Strasbourg Cathedral to Frankfurt am Main. However, there are services departing from Strasbourg Cathedral station and arriving at Frankfurt am Main station via Karlsruhe central train station station. The journey, including transfers, takes approximately 4h 20m.
Strasbourg Cathedral to Frankfurt am Main bus services, operated by FlixBus, depart from Strasbourg station.
Strasbourg Cathedral to Frankfurt am Main bus services, operated by FlixBus, arrive at Frankfurt central train station.
Book your Strasbourg Cathedral to Frankfurt am Main bus tickets online with FlixBus and BlaBlaCar Bus.
The distance between Strasbourg Cathedral and Frankfurt am Main is 183.5 km. The road distance is 245 km.
You can take a vehicle from Strasbourg Cathedral to Frankfurt central train station via Strasbourg and Karlsruhe central train station in around 4h 25m.