The average bus between Strasbourg and Main takes 6h 13m and the fastest bus takes 5h 2m. The bus service runs several times per day from Strasbourg to Main. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Strasbourg and Main. The earliest departure is at 3:30 AM at night, and the last departure from Strasbourg is at 8:35 PM which arrives into Main at 6:57 AM. All services require a transfer at Frankfurt - Airport Bus Station and take an average of 6h 13m. The schedules shown below are for the next available departures.


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5h 32m • 2 changesWant to know about travelling from Strasbourg to Main? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Strasbourg to Main. However, there are services departing from Strasbourg station and arriving at Main station via Frankfurt - Airport Bus Station station. The journey, including transfers, takes approximately 6h 13m.
Strasbourg to Main bus services, operated by FlixBus, depart from Strasbourg - L'Étoile Park Bus Station.
Strasbourg to Main bus services, operated by FlixBus, arrive at Frankfurt - Airport Bus Station.
The distance between Strasbourg and Main is 161.8 km. The road distance is 244 km.
BlaBlaCar Bus operates a bus from Strasbourg - L'Étoile Park Bus Station to Frankfurt - Airport Bus Station every 4 hours. Tickets cost €18–35 and the journey takes 3h 55m. FlixBus also services this route every 4 hours.