The average bus between Sunnyvale and South San Francisco takes 2h 29m and the fastest bus takes 1h 51m. The bus runs at least 3 times per hour from Sunnyvale to South San Francisco. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 20 minutes between Sunnyvale and South San Francisco. The earliest departure is at 7:50 AM in the morning, and the last departure from Sunnyvale is at 10:27 PM which arrives into South San Francisco at 12:38 AM. All services require a transfer, and take on average 2h 29m. The schedules shown below are for the next available departures.

2h 33m • 1 change

2h 35m • 1 change

2h 35m • 1 change

2h 34m • 1 change
Want to know about travelling from Sunnyvale to South San Francisco? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Sunnyvale to South San Francisco. However, there are services departing from Sunnyvale station and arriving at South San Francisco station via Palo Alto Transit Center. The journey, including transfers, takes approximately 2h 29m.
Sunnyvale to South San Francisco bus services, operated by Santa Clara VTA, depart from El Camino & Mathilda station.
Sunnyvale to South San Francisco bus services, operated by Santa Clara VTA, arrive at San Bruno BART-Bay 5 station.
The distance between Sunnyvale and South San Francisco is 45.6 km. The road distance is 48 km.
You can take a bus from El Camino & Mathilda to San Bruno BART-Bay 5 via Palo Alto Transit Ctr-Bay 9 in around 2h 21m.