The average bus between Syracuse and Charlotte takes 20h 40m and the fastest bus takes 19h 5m. The bus service runs several times per day from Syracuse to Charlotte. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Syracuse and Charlotte. The earliest departure is at 2:30 AM at night, and the last departure from Syracuse is at 2:00 PM which arrives into Charlotte at 9:05 AM. All services require a transfer, and take on average 20h 40m. The schedules shown below are for the next available departures.
Arrives next day

22h 15m • 1 change
Arrives next day

19h 5m • 1 change
Arrives next day

22h 15m • 1 change
Arrives next day

19h 5m • 1 change
Arrives next day

22h 15m • 1 change
Arrives next day

19h 5m • 1 change
Arrives next day

22h 15m • 1 change
Arrives next day

19h 5m • 1 change
Want to know about travelling from Syracuse to Charlotte? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Syracuse to Charlotte. However, there are services departing from Syracuse station and arriving at Charlotte station via Newark Penn Station station. The journey, including transfers, takes approximately 20h 40m.
Syracuse to Charlotte bus services, operated by Flixbus USA, depart from Syracuse Bus Station.
Syracuse to Charlotte bus services, operated by Flixbus USA, arrive at Charlotte Bus Station.
Book your Syracuse to Charlotte bus tickets online with Flixbus USA and Greyhound USA.
The distance between Syracuse and Charlotte is 958.9 km. The road distance is 1,382 km.
You can take a bus from Syracuse Bus Station to Charlotte Bus Station via Newark Penn Station in around 18h.