The average bus between Syracuse and Wayne takes 6h 11m and the fastest bus takes 5h 21m. The bus service runs several times per day from Syracuse to Wayne. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Syracuse and Wayne. The earliest departure is at 2:35 AM at night, and the last departure from Syracuse is at 5:55 PM which arrives into Wayne at 11:16 PM. All services require a transfer at New York and take an average of 6h 11m. The schedules shown below are for the next available departures.

6h 3m • 1 change

5h 27m • 1 change

5h 42m • 1 change

5h 21m • 1 change

6h 3m • 1 change

7h 9m • 1 change

5h 27m • 1 change

5h 42m • 1 change

6h 3m • 1 change

7h 9m • 1 change

5h 27m • 1 change

5h 42m • 1 change
Want to know about travelling from Syracuse to Wayne? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Syracuse to Wayne. However, there are services departing from Syracuse station and arriving at Wayne station via New York. The journey, including transfers, takes approximately 6h 11m.
Syracuse to Wayne bus services, operated by Trailways, depart from Syracuse station.
Syracuse to Wayne bus services, operated by Trailways, arrive at Mothers Park & Ride Rt 23 North station.
The distance between Syracuse and Wayne is 282.2 km. The road distance is 513 km.
You can take a bus from Syracuse to Mothers Park & Ride Rt 23 North via New York and Port Authority Bus Terminal in around 5h 37m.