The average bus between Tallahassee and Florida Keys takes 20h 43m and the fastest bus takes 18h 5m. The bus service runs several times per day from Tallahassee to Florida Keys. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Tallahassee and Florida Keys. The earliest departure is at 11:50 AM in the morning, and the last departure from Tallahassee is at 9:05 PM which arrives into Florida Keys at 3:10 PM. All services require a transfer at Miami Airport Station and take an average of 20h 43m. The schedules shown below are for the next available departures.
Arrives next day


24h 25m • 2 changes
Arrives next day


18h 5m • 2 changes
Arrives next day


24h 25m • 2 changes
Arrives next day


18h 5m • 2 changes
Arrives next day


24h 25m • 2 changes
Arrives next day


18h 5m • 2 changes
Arrives next day


24h 25m • 2 changes
Arrives next day


18h 5m • 2 changes
Want to know about travelling from Tallahassee to Florida Keys? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Tallahassee to Florida Keys. However, there are services departing from Tallahassee station and arriving at Florida Keys station via Miami Airport Station station. The journey, including transfers, takes approximately 20h 43m.
Tallahassee to Florida Keys bus services, operated by Greyhound USA, depart from Tallahassee station.
Tallahassee to Florida Keys bus services, operated by Greyhound USA, arrive at Big Pine Key station.
The distance between Tallahassee and Florida Keys is 697.4 km. The road distance is 1,132 km.
You can take a bus from Tallahassee to Florida Keys via Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 19h 10m.