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Tampa to Des Moines buses

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Trip Overview

The bus between Tampa and Des Moines takes 2d 2h. The bus runs, on average, 4 times per week from Tampa to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 2h
Duration
1,521 mi
Distance
$300
Average price
4 times a week
Frequency

Tampa to Des Moines bus times

Buses run 4 times a week between Tampa and Des Moines. The service departs Tampa at 8:15 PM in the evening, which arrives into Des Moines at 21:45:00. All services require a transfer at Atlanta Bus Station and take an average of 2d 2h. The schedules shown below are for the next available departures.

Departing Thursday, October 22, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA2d 2h • 2 changes

Departing Friday, October 23, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA2d 2h • 2 changes

Departing Saturday, October 24, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA2d 2h • 2 changes

Departing Sunday, October 25, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA2d 2h • 2 changes

Frequently asked questions

Want to know about travelling from Tampa to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Tampa to Des Moines.ExpandLaunch map view
  • Distance: 1,521.4 mi
  • Duration: 2d 2h

What companies run services between Tampa, FL, USA and Des Moines, IA, USA?

You can take a bus from Tampa Bus Station to Des Moines via Atlanta Bus Station and Indianapolis Union Station in around 32h 55m.

Operators