The average bus between Tustin and Otay Mesa takes 4h 14m and the fastest bus takes 3h 9m. The bus service runs several times per day from Tustin to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Tustin and Otay Mesa. The earliest departure is at 5:55 AM in the morning, and the last departure from Tustin is at 10:05 PM which arrives into Otay Mesa at 5:03 AM. All services require a transfer at San Ysidro and take an average of 4h 14m. The schedules shown below are for the next available departures.


3h 19m • 2 changes


3h 44m • 2 changes


3h 54m • 2 changes


3h 19m • 2 changes


3h 9m • 2 changes


3h 34m • 2 changes


3h 19m • 2 changes


3h 44m • 2 changes


3h 19m • 2 changes


3h 44m • 2 changes


3h 19m • 2 changes


3h 44m • 2 changes


3h 19m • 2 changes


3h 44m • 2 changes
Want to know about travelling from Tustin to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Tustin to Otay Mesa. However, there are services departing from Tustin station and arriving at Otay Mesa station via San Ysidro. The journey, including transfers, takes approximately 4h 14m.
Tustin to Otay Mesa bus services, operated by Greyhound USA, depart from Santa Ana station.
Tustin to Otay Mesa bus services, operated by Greyhound USA, arrive at San Ysidro station.
The distance between Tustin and Otay Mesa is 152.9 km. The road distance is 189 km.
Limousine Express operates a bus from Santa Ana to San Ysidro 5 times a day, and the journey takes 1h 50m. Four other operators also service this route.