Tustin to Otay Mesa Buses

Trip Overview

The average bus between Tustin and Otay Mesa takes 4h 16m and the fastest bus takes 3h 9m. The bus service runs several times per day from Tustin to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 16m
Duration: 118 mi
Distance: $34
Average price: Every 4 hours
Frequency

Bus

best

Take the bus from Santa Ana to San Ysidrobus Lxus 3105 / ...

2h 51m

$22–40

Tustin to Otay Mesa bus times

Buses run every 4 hours between Tustin and Otay Mesa. The earliest departure is at 5:55 AM in the morning, and the last departure from Tustin is at 10:05 PM which arrives into Otay Mesa at 5:03 AM. All services require a transfer at San Ysidro and take an average of 4h 16m. The schedules shown below are for the next available departures.

Departing Sunday, November 1, 2026

5:55 AM → 7:09 AM
4h 14m • 2 changes
9:00 AM → 12:09 PM
3h 9m • 2 changes
9:10 AM → 10:09 AM
3h 59m • 2 changes
2:35 PM → 6:09 PM
3h 34m • 2 changes
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Departing Monday, November 2, 2026

5:55 AM → 6:54 AM
3h 59m • 2 changes
9:10 AM → 10:19 AM
4h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
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Departing Tuesday, November 3, 2026

5:55 AM → 6:54 AM
3h 59m • 2 changes
9:10 AM → 10:19 AM
4h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Departing Wednesday, November 4, 2026

5:55 AM → 6:54 AM
3h 59m • 2 changes
9:10 AM → 10:19 AM
4h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Departing Thursday, November 5, 2026

5:55 AM → 6:54 AM
3h 59m • 2 changes
9:10 AM → 10:19 AM
4h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Departing Friday, November 6, 2026

5:55 AM → 6:54 AM
3h 59m • 2 changes
9:10 AM → 10:19 AM
4h 9m • 2 changes
10:00 AM → 1:19 PM
3h 19m • 2 changes
2:35 PM → 6:19 PM
3h 44m • 2 changes
Show more

Departing Saturday, November 7, 2026

5:55 AM → 7:54 AM
4h 59m • 2 changes
9:10 AM → 10:54 AM
4h 44m • 2 changes
10:00 AM → 1:54 PM
3h 54m • 2 changes
2:35 PM → 5:54 PM
3h 19m • 2 changes
Show more

Frequently asked questions

Want to know about travelling from Tustin to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

What companies run services between Tustin, CA, USA and Otay Mesa, CA, USA?

Limousine Express operates a bus from Santa Ana to San Ysidro 5 times a day. Tickets cost $30–45 and the journey takes 1h 50m. Two other operators also service this route.

Operators