The average bus between Twickenham and Southampton takes 2h 35m and the fastest bus takes 2h 8m. There is a bus service every few hours from Twickenham to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Twickenham and Southampton. The earliest departure is at 12:39 AM at night, and the last departure from Twickenham is at 11:21 PM which arrives into Southampton at 1:30 AM. All services require a transfer, and take on average 2h 35m. The schedules shown below are for the next available departures.

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Want to know about travelling from Twickenham to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Twickenham to Southampton. However, there are services departing from Twickenham station and arriving at Southampton station via Heathrow Terminal 5. The journey, including transfers, takes approximately 2h 35m.
Twickenham to Southampton bus services, operated by Abellio London, depart from Heath Road / Grove Avenue station.
Twickenham to Southampton bus services, operated by Abellio London, arrive at Coach Station.
The distance between Twickenham and Southampton is 95.6 km. The road distance is 122 km.
You can take a bus from Heath Road / Grove Avenue to Coach Station via Heathrow Terminal 5 in around 2h 53m.