The average bus between Tyler and San Antonio takes 8h 15m and the fastest bus takes 8h. The bus service runs several times per day from Tyler to San Antonio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Tyler and San Antonio. The earliest departure is at 10:50 AM in the morning, and the last departure from Tyler is at 9:00 PM which arrives into San Antonio at 5:00 AM. All services require a transfer, and take on average 8h 15m. The schedules shown below are for the next available departures.

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Want to know about travelling from Tyler to San Antonio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Tyler to San Antonio. However, there are services departing from Tyler station and arriving at San Antonio station via Dallas Bus Station station. The journey, including transfers, takes approximately 8h 15m.
Tyler to San Antonio bus services, operated by Greyhound USA, depart from Tyler station.
Tyler to San Antonio bus services, operated by Greyhound USA, arrive at San Antonio Bus Station.
Book your Tyler to San Antonio bus tickets online with Greyhound USA.
The distance between Tyler and San Antonio is 445.8 km. The road distance is 622 km.
You can take a bus from Tyler to San Antonio Bus Station via Dallas Bus Station in around 8h.