The average bus between Uxbridge and Southampton takes 2h 26m and the fastest bus takes 2h 6m. There is a bus service every few hours from Uxbridge to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Uxbridge and Southampton. The earliest departure is at 12:35 AM at night, and the last departure from Uxbridge is at 11:24 PM which arrives into Southampton at 1:30 AM. All services require a transfer, and take on average 2h 26m. The schedules shown below are for the next available departures.

2h 33m • 1 change

2h 28m • 1 change

2h 35m • 1 change

2h 44m • 1 change

2h 25m • 1 change

2h 34m • 1 change

2h 35m • 1 change

2h 23m • 1 change

2h 25m • 1 change

2h 34m • 1 change

2h 35m • 1 change

2h 23m • 1 change

2h 25m • 1 change

2h 35m • 1 change

2h 17m • 1 change

2h 20m • 1 change
Want to know about travelling from Uxbridge to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Uxbridge to Southampton. However, there are services departing from Uxbridge station and arriving at Southampton station via Coach Station station. The journey, including transfers, takes approximately 2h 26m.
Uxbridge to Southampton bus services, operated by Metroline Travel, depart from Heathrow Central Bus Station.
Uxbridge to Southampton bus services, operated by Metroline Travel, arrive at Coach Station.
The distance between Uxbridge and Southampton is 96.3 km. The road distance is 119 km.
National Express operates a bus from Heathrow Central Bus Station to Coach Station hourly. Tickets cost £12–30 and the journey takes 1h 50m.