The average bus between Uxbridge and Southampton Central Station takes 2h 26m and the fastest bus takes 2h 6m. There is a bus service every few hours from Uxbridge to Southampton Central Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Uxbridge and Southampton Central Station. The earliest departure is at 12:35 AM at night, and the last departure from Uxbridge is at 11:24 PM which arrives into Southampton Central Station at 1:30 AM. All services require a transfer at Heathrow Central Bus Station and take an average of 2h 26m. The schedules shown below are for the next available departures.

2h 20m • 1 change

2h 30m • 1 change

2h 30m • 1 change

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2h 24m • 1 change

2h 44m • 1 change

2h 20m • 1 change

2h 11m • 1 change

2h 24m • 1 change

2h 34m • 1 change

2h 35m • 1 change

2h 23m • 1 change

2h 25m • 1 change

2h 34m • 1 change

2h 35m • 1 change

2h 23m • 1 change
Want to know about travelling from Uxbridge to Southampton Central Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Uxbridge to Southampton Central Station. However, there are services departing from Uxbridge station and arriving at Southampton Central Station station via Coach Station station. The journey, including transfers, takes approximately 2h 26m.
Uxbridge to Southampton Central Station bus services, operated by Metroline Travel, depart from Heathrow Central Bus Station.
Uxbridge to Southampton Central Station bus services, operated by Metroline Travel, arrive at Coach Station.
The distance between Uxbridge and Southampton Central Station is 96.4 km. The road distance is 118 km.
National Express operates a bus from Heathrow Central Bus Station to Coach Station hourly. Tickets cost £12–35 and the journey takes 1h 50m.