The average bus between Van Nuys and San Ysidro takes 5h 40m and the fastest bus takes 5h 8m. The bus service runs several times per day from Van Nuys to San Ysidro. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Van Nuys and San Ysidro. The earliest departure is at 8:22 AM in the morning, and the last departure from Van Nuys is at 10:03 PM which arrives into San Ysidro at 3:56 AM. All services require a transfer at Chandler / Lankershim and take an average of 5h 40m. The schedules shown below are for the next available departures.


5h 23m • 2 changes


5h 8m • 2 changes


5h 8m • 2 changes


5h 8m • 2 changes


5h 8m • 2 changes
Want to know about travelling from Van Nuys to San Ysidro? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Van Nuys to San Ysidro. However, there are services departing from Van Nuys station and arriving at San Ysidro station via San Ysidro. The journey, including transfers, takes approximately 5h 40m.
Van Nuys to San Ysidro bus services, operated by Metro Los Angeles, depart from Los Angeles Union Station.
Van Nuys to San Ysidro bus services, operated by Metro Los Angeles, arrive at San Ysidro station.
The distance between Van Nuys and San Ysidro is 223.8 km. The road distance is 255 km.
Greyhound Mexico operates a bus from Los Angeles Union Station to San Ysidro 3 times a day. Tickets cost $26–45 and the journey takes 3h 30m.