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Vatican City to Siena buses

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Trip Overview

The average bus between Vatican City and Siena takes 4h 36m and the fastest bus takes 3h 20m. The bus service runs several times per day from Vatican City to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 36m
Duration
236 km
Distance
€21
Average price
3 times a day
Frequency

Vatican City to Siena bus times

Buses run 3 times a day between Vatican City and Siena. The earliest departure is at 5:36 AM in the morning, and the last departure from Vatican City is at 4:20 PM which arrives into Siena at 8:24 PM. All services require a transfer, and take on average 4h 36m. The schedules shown below are for the next available departures.

Departing Friday, November 6, 2026

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    Cotral S.p.A.FlixBus3h 29m • 1 change
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    Cotral S.p.A.FlixBus3h 49m • 1 change

Departing Saturday, November 7, 2026

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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 38m • 1 change
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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 35m • 1 change
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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 20m • 1 change
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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 20m • 1 change
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Departing Sunday, November 8, 2026

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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 30m • 1 change
  •  → 

    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 35m • 1 change
  •  → 

    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 20m • 1 change
  •  → 

    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 20m • 1 change
  • Show more

Departing Monday, November 9, 2026

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    Cotral S.p.A.FlixBus3h 29m • 1 change
  •  → 

    Cotral S.p.A.FlixBus3h 49m • 1 change

Departing Tuesday, November 10, 2026

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    Cotral S.p.A.FlixBus3h 29m • 1 change
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    Cotral S.p.A.FlixBus8h 14m • 1 change

Departing Wednesday, November 11, 2026

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    Cotral S.p.A.FlixBus8h 14m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Cotral S.p.A.FlixBus3h 29m • 1 change
  •  → 

    Cotral S.p.A.FlixBus3h 49m • 1 change

Frequently asked questions

Want to know about travelling from Vatican City to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Vatican City to Siena.ExpandLaunch map view
  • Distance: 236 km
  • Duration: 4h 36m

What companies run services between Vatican City and Siena, Italy?

FlixBus operates a bus from Roma, Autostazione Tiburtina to Siena hourly. Tickets cost €20–30 and the journey takes 2h 40m. AutoLinee Moretti also services this route 3 times a week.

Operators